Mamidi Health

What is AIVA?

AIVA (AI-assisted Variant Analysis) is an AI-powered genomic diagnostics platform designed for diagnostic labs. It acts as your AI Clinical Analyst, powered by a 4M+ connection knowledge graph (AIVA-KG) to automate variant analysis and deliver genetic interpretations in 10 minutes instead of weeks. AIVA combines natural language interaction with ACMG-compliant classification to eliminate expert bottlenecks, with zero data retention for complete privacy.

How does AIVA work?

AIVA integrates into your existing genomic workflow after sequencing and secondary analysis. You upload your VCF files from any pipeline, and AIVA performs tertiary analysis. Through natural conversation, you can ask questions, filter variants, and get instant ACMG-compliant classifications with detailed evidence summaries. Clinical reports are generated in your lab's exact format with one click.

Who is AIVA designed for?

AIVA is built for diagnostic laboratories performing genomic testing, including clinical labs, genetic testing providers, and research institutions. It serves lab directors, genetic counselors, variant analysts, clinical specialists, and bioinformaticians who need to analyze genetic variants efficiently while maintaining clinical accuracy and regulatory compliance.

How fast is AIVA compared to traditional genetic analysis?

AIVA delivers sample-to-insights in just 10 minutes. From VCF upload to clinical-grade report, what traditionally takes weeks of expert review is completed in minutes. AIVA can query 5 million variants in under 1 second, and each AI query takes less than 1 minute to search literature, query databases, and filter variants.

How long does it take to generate a clinical report with AIVA?

Clinical reports are generated instantly with AIVA. Traditional report generation takes days because analysts must manually compile findings, gather evidence, and format documentation. AIVA automates this entire process, producing custom clinical reports in your lab's exact format with one click.

How many cases can a specialist handle with AIVA?

Each specialist can handle 5-10x more cases when using AIVA. By reducing per-case analysis time from hours to minutes, AIVA allows your existing team to dramatically increase throughput without sacrificing accuracy or thoroughness. This means labs can scale their testing capacity without proportionally increasing staff.

What is ACMG/AMP variant classification?

ACMG/AMP variant classification is the gold standard framework established by the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) for interpreting genetic variants. It categorizes variants into five classes: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, and Benign. AIVA applies these criteria systematically and automatically, ensuring every classification meets clinical standards.

How accurate is AIVA's variant analysis?

AIVA ensures high accuracy through systematic application of ACMG/AMP criteria, real-time variant-disease association matching, and comprehensive evidence gathering from genomic databases and literature. Every classification includes detailed evidence summaries so analysts can verify the reasoning.