Fernwell — Rooted in Your Wellbeing

Which one is right for you?

The honest answer is: it depends on your diagnosis, your insurance, and your provider's judgment.

What about compounded GLP-1s?

During the semaglutide shortage, the FDA allowed compounding pharmacies to produce semaglutide. Many telehealth platforms now offer compounded semaglutide at significantly lower prices than branded versions. Compounded tirzepatide is also available through some providers. Compounded GLP-1s are not FDA-approved as branded drugs are, but they contain the same active ingredient.

Side effects: are they the same?

The side effect profiles are similar across all four medications — nausea, vomiting, constipation, and diarrhea are the most common, especially when starting or increasing dose. Tirzepatide may have a slightly different tolerability profile for some patients. See our full side effects guide for practical management tips.

What if your doctor says no?

Some primary care doctors are still cautious about prescribing GLP-1s for weight loss, particularly without a diabetes diagnosis. If this happens, you have options: Ask for a referral to an endocrinologist or obesity medicine specialist — they're typically more comfortable prescribing GLP-1s for weight management.

What to do if you're denied?

Insurance denials are not the end of the road. Approximately 40–60% of GLP-1 prior authorization appeals succeed with proper documentation. Step 1: Request the denial reason in writing You're entitled to a written explanation of any coverage denial. This tells you exactly what to address in your appeal. Step 2: File a formal appeal Your insurer must have an appeals process.